荷兰一项研究显示，红酒中的“神奇物质”白藜芦醇能减少肥胖对身体的负面影响，降低肥胖人士年老后罹患疾病的风险。
研究报告由最新一期美国《细胞－代谢》月刊发表。
荷兰马斯特里赫特大学研究人员给11名肥胖男性每天注射含150毫克白藜芦醇的针剂。一个月后，这些人的收缩压降低5毫米汞柱，新陈代谢速度放缓，身体能量消耗减少2%至4%。
研究人员说，新陈代谢速度放缓意味着人不需要像以前吃得那么多，仍可以维持身体正常运转。这样可减少肥胖人士肝脏部位聚积的脂肪，降低血压和血糖。
英国媒体11月1日援引研究负责人马斯特里赫特大学教授施拉乌文的话报道，白藜芦醇对肥胖人士的作用微小却重要，“在我看来，它们（白藜芦醇）的作用非常稳定，让许多参数发生细微变化”。
“我们只注射30天，还不清楚长时间注射会产生什么结果，”他说，“新陈代谢变化需要一段时间才能显现出来，因此，（白藜芦醇）给身体带来的影响可能更明显”。
白藜芦醇存在于红酒、葡萄、桑葚和花生中。不过，要想通过饮用红酒获得实验中11名肥胖者的效果，每天必须喝下13瓶酒才够，这样做显然弊大于利。（生物谷 Bioon.com）
doi:10.1016/j.cmet.2011.10.002
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Silvie Timmers, Ellen Konings, Lena Bilet, Riekelt H. Houtkooper, Tineke van de Weijer, Gijs H. Goossens, Joris Hoeks, Sophie van der Krieken, Dongryeol Ryu, Sander Kersten, Esther Moonen-Kornips, Matthijs K.C. Hesselink, Iris Kunz, Vera B. Schrauwen-Hinderling, Ellen E. Blaak, Johan Auwerx, Patrick Schrauwen
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
