近日，厦门大学韩家淮教授课题组在国际权威刊物《自然—免疫学》（Nature Immunology）发表题为“Programmed necrosis： backup to and competitor with apoptosis in the immune system”的综述性文章。
程序性细胞死亡对于免疫系统的发展、维持以及对外源、内源刺激所作出的反应都极为重要。研究证实除caspase-依赖的凋亡途径外，依赖于激酶RIP1和RIP3的程序性坏死途径也是一条在发育和免疫过程中起主要作用的程序性细胞死亡通路。这两种通路可能存在着互相抑制的现象，并且当caspase-依赖的凋亡途径被抑制或者缺失时，程序性坏死途径将作为备选项继续行使功能。本文总结了近期的相关研究，对程序性坏死的分子机制以及凋亡和程序性坏死之间相互调节的机制进行了系统地阐述。（生物谷Bioon.com)
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doi:10.1038/ni.2159
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Programmed necrosis: backup to and competitor with apoptosis in the immune system
Jiahuai Han, Chuan-Qi Zhong & Duan-Wu Zhang
Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed cell-death pathway in development and immunity. These two programmed cell-death pathways may suppress each other, and necroptosis also serves as an alternative when caspase-dependent apoptosis is inhibited or absent. Here we summarize recent advancements that have identified the molecular mechanisms that underlie necroptosis and explore the mechanisms that regulate the interplay between apoptosis and necroptosis.
