纽约医学院心血管研究所主任Piero Anversa医学博士再次证明，心脏有自己独特的用来心脏病发作后再生心肌组织的成体干细胞。这篇研究发表在9月19日期的《细胞》杂志上，建立在几周前在《美国科学院院刊》(PNAS)上发表的一篇研究之上。
《细胞》上的这篇研究是在Anversa博士的实验室中进行的，由Anversa博士、Bernardo Nadal-Ginard博士、Annarosa Leri医学博士和Jan Kajstura博士领导的研究小组完成。“直到最近，心脏生物学的理论还普遍认为成熟哺乳动物的心脏是没有再生能力的后有丝分裂器官。也就是说从刚出生到成年到衰老，心脏的心肌细胞数量相对稳定但又还面减少。但越来越多的证据向这个观点提出了挑战。
Anversa博士在心力衰竭研究中发现了大量证据证明心脏具有自我修复能力，从而驳斥了干细胞只能从血液、皮肤、中枢神经系统、肝脏、胃肠道和骨骼肌等成熟组织中获得的观点。在《细胞》的这篇研究中，Anversa和他的同事使用了分离自成年大鼠心脏的特殊细胞，这些细胞都有心脏祖细胞的性质。他们将富含这些心脏祖细胞的混合物导入肌肉萎缩的心脏，结果心脏产生了在结构和功能上够能胜任的新心肌细胞以及平滑肌细胞和内皮细胞。
“我们已经识别出这些干细胞存在于何处，正在想办法使它们迁移到心脏受损部位。到时我们会将I期临床试验的草案呈交给FDA审批。”Anversa博士表示
参考：
Hope for a Broken Heart?
Leslie A. Leinwand
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Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio P. Beltrami, Laura Barlucchi, Daniele Torella, Mathue Baker, Federica Limana, Stefano Chimenti, Hideko Kasahara, Marcello Rota, Ezio Musso, Konrad Urbanek, Annarosa Leri, Jan Kajstura, Bernardo Nadal-Ginard, and Piero Anversa
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