Epidermal Viral Immunity Induced by CD8+ Dendritic Cells But Not by Langerhans Cells
Rhys S. Allan, Chris M. Smith, Gabrielle T. Belz, Allison L. van Lint, Linda M. Wakim, William R. Heath, and Francis R. Carbone
Science Sep 26 2003: 1925-1928. [Abstract] [Full Text] [PDF] [Supporting Online Material]
The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8+ dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.
