生物谷报道：今天出版的Science以封面文章刊登了华人科学家童hin-yan的文章，首次全面揭示了酵母中1000左右基因和4000种相互作用关系，这一重大研究成果首次揭示了一种生物的全部基因间的相互作用图谱，是功能基因组学研究的重大突破，也为今后其它物种的相关研究开创新时代。
Global Mapping of the Yeast Genetic Interaction Network
Amy Hin Yan Tong,1,2* Guillaume Lesage,3* Gary D. Bader,4 Huiming Ding,1 Hong Xu,1,2 Xiaofeng Xin,1,2 James Young,6 Gabriel F. Berriz,7 Renee L. Brost,1 Michael Chang,5 YiQun Chen,1 Xin Cheng,1 Gordon Chua,1 Helena Friesen,2 Debra S. Goldberg,7 Jennifer Haynes,2 Christine Humphries,2 Grace He,1 Shamiza Hussein,3 Lizhu Ke,1 Nevan Krogan,1,2 Zhijian Li,1,2 Joshua N. Levinson,3 Hong Lu,1 Patrice Ménard,3 Christella Munyana,3 Ainslie B. Parsons,1,2 Owen Ryan,1 Raffi Tonikian,1,2 Tania Roberts,5 Anne-Marie Sdicu,3 Jesse Shapiro,3 Bilal Sheikh,1 Bernhard Suter,8 Sharyl L. Wong,7 Lan V. Zhang,7 Hongwei Zhu,1 Christopher G. Burd,9 Sean Munro,10 Chris Sander,4 Jasper Rine,8 Jack Greenblatt,1,2 Matthias Peter,11 Anthony Bretscher,6 Graham Bell,3 Frederick P. Roth,7 Grant W. Brown,5 Brenda Andrews,2 Howard Bussey,3 Charles Boone1,2
Science 2004 303: 808-813
A genetic interaction network containing 1000 genes and 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.
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Science 2004 303: 774-775. (in Perspectives) [Summary] [Full Text]
