生物谷报道：朊病毒，有人认为该称为蛋白感染子，因为它是一种蛋白质，但却具有自身复制能力，并可以将正常蛋白变成异常的蛋白，具有病毒相似的特征，因此成为研究热点。以前认为朊病毒是引发疯牛病的主要蛋白，后来在正常的的神经系统内也发现了它，而近年研究又发现它与神经细胞的生长和凋亡有关，下边附有生物谷以前的相关报道。而且发现在低等的生物，如酵母中也有存在类似朊病毒行为的蛋白，这似乎表现朊病毒无处不在，包括极低等的生物中。今天刚刚出版的Nature上，以及近来发表现PNAS等刊物上有许多相关的研究。生物谷将最新的文献收集整理，供大家分享。
Supattapone S.Prion protein conversion in vitro.
J Mol Med. 2004 Mar 10
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DeMarco ML, Daggett V.From conversion to aggregation: protofibril formation of the prion protein.
Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2293-8.
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Scheibel T, Bloom J, Lindquist SL.The elongation of yeast prion fibers involves separable steps of association and conversion.
Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2287-92.
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Goodman L.Assessing risk is the business of prion disease research.
J Clin Invest. 2004 Feb;113(4):494.
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DeMarco ML, Daggett V.From conversion to aggregation: Protofibril formation of the prion protein.Proc Natl Acad Sci U S A. 2004 Feb 13
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Favereaux A, Perret-Liaudet A, Vital A.Extraneural pathologic prion protein.
N Engl J Med. 2004 Feb 12;350(7):732-3;
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Apetri AC, Surewicz KA, Surewicz WK.The effect ofdisease-associated mutations on the folding pathway of human prion protein.
J Biol Chem. 2004 Feb 2 PDF
Protein-only transmission of three yeast prion strains
CHIH-YEN KING & RUBEN DIAZ-AVALOS
Nature 428, 319–323 (2004); doi:10.1038/nature02391
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Conformational variations in an infectious protein determine prion strain differences
MOTOMASA TANAKA, PETER CHIEN, NARIMAN NABER, ROGER COOKE & JONATHAN S. WEISSMAN
Nature 428, 323–328 (2004); doi:10.1038/nature02392
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Cell biology: The strain of being a prion
MICK F. TUITE
Prions are remarkable infectious agents associated with certain brain diseases. But they also occur in fungi, experiments with which now provide plausible answers to some critical questions about prion biology.
Nature 428, 265–267 (2004); doi:10.1038/428265a
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