生物谷报道：最新一项研究表明，大脑的A型钾通道直接与颞叶癫痫相关，它是最常见的一种癫痫类型。这种通道的转录水平改变，或转录后的翻译水平改变，导致通道的数量变化，从而直接影响了海马CA1区细胞的激活方式，从而成为了癫痫诱发的真正原因。在遗传性癫痫中也有类似情况，这一研究从细胞离子通道角度揭示了癫痫的电生理学原理。这篇文章发表在刚刚出版的Science上.
channelopathies are at the origin of many neurological disorders. Here we report a form of channelopathy that is acquired in experimental temporal lobe epilepsy (TLE), the most common form of epilepsy in adults. The excitability of CA1 pyramidal neuron dendrites was increased in TLE because of decreased availability of A-type potassium ion channels due to transcriptional (loss of channels) and posttranslational (increased channel phosphorylation by extracellular signal-regulated kinase) mechanisms. Kinase inhibition partly reversed dendritic excitability to control levels. Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE.
