根据美国牙周病学会最新发表在《牙周病学》杂志中的研究结果显示，口腔中存在的一种特殊细菌与牙周袋中的细菌成分可解释牙周病和急性冠状动脉综合征（ACS）之间的相关性。
研究发现，ACS患者群体的口腔细菌如streptococci spp、P. gingivalis、T. forsythia和T. denticola等的数量提高了两倍多，研究结果显示了这些细菌与牙周炎和ACS的感染病原学中有相似之处。
该研究结果可能解释为什么提高细菌含量和结合特殊病原物可能同时与牙周病及ACS的发生相关。同时，研究人员也发现牙周病细菌导致炎症应答，并增加白细胞数量及其对C反应蛋白水平的高灵敏度，这些因子都是先前研究发现与心脏病相关的。
此外，研究也发现牙槽骨丢失的增加能明显提高ACS风险系数。77％的ACS群体和42％对照群体的受试者有明显的牙周炎迹象。与非ACS群体相比，ACS群体中的骨质丢失增加导致的后果更为严重。
患者口腔细菌含量较高的另一个原因可能归咎于易受传染性和缺乏足够的宿主产生炎症应答，其中可能包括其它的系统血管影响导致了ACS发病。
尽管该研究与先前研究结果一致，目前尚需进一步研究来确定减少特定细菌数量在降低ACS风险性中的作用。同时，该数据也强调了常规牙周病与家庭牙科护理的重要性。
英文原文：
Periodontal bacteria may be linked to acute coronary syndrome (ACS)
By American Academy of Periodontology, The presence of specific bacteria and combinations of bacteria in periodontal pockets might be an explanation for the relationship between periodontal disease and acute coronary syndrome (ACS), according to a new study published in the Journal of Periodontology.
The amount of oral bacteria was two times higher in the ACS group for the combination of the bacteria streptococci spp, P. gingivalis, T. forsythia and T. denticola. Specifically, the findings suggest that T. denticola, T. forsythia and streptococci spp are bacteria in a shared infectious etiology for periodontitis and ACS.
"This might be one of several explanations as to why elevated bacteria and the combination of specific pathogens in periodontal pockets can be linked to a history of ACS," said Stefan Renvert, DDS, PhD and Department of Health Sciences, Kristianstad University. "We also found that the amount of periodontal bacteria results in an inflammatory response that elevates the white blood cell counts and high sensitivity C-reactive protein levels, which has also been linked in past studies to heart disease."
It was also found that the extent of alveolar bone loss was significantly greater among subjects with ACS. Seventy-seven percent of the participants in the ACS group and 42 percent in the control group demonstrated evidence of periodontitis. The extent of bone loss was more severe in the ACS group than in the non-ACS group.
Another reason people diagnosed with ACS may have higher oral bacteria could be due to their infectious susceptibility and lack of an adequate host inflammatory response, which may induce other systemic vascular effects participating in the onset of ACS.
"Although this study supports past findings, further research is needed to evaluate the effects of reducing specific bacteria such as T. forsythia and T. denticola on reducing the risk for ACS," said Kenneth A. Krebs, DMD and AAP president. "This data highlights the importance of routine periodontal examinations and at-home dental care."
