一项新的研究揭示了真核细胞中翻译过程的起始因子(Initiation Factor;IF)4A,即eIF4A(eukaryotic translation initiation factor 4A)在抑制Decapentaplegic(Dpp)信号通路过程中的作用。在Dpp信号通路的激活过程中,eIF4A通过非翻译依赖性的方式,促进了下游信号成员Mad 和Medea的降解。感兴趣的读者可以查阅英文原文。
深入阅读:
1.eIF4A goes beyond translation
Nature Cell Biology - 8, 1319 - 1321 (2006)
Markus Affolter & George Pyrowolakis
2.A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation
Nature Cell Biology - 8, 1407 - 1414 (2006)
Jinghong Li & Willis X. Li