生物谷报道：心脏增大或心肌肥大是对工作量增大的一种生理反应，帮助维持心脏功能。然而，如果这种状况时间长了，它会发展成心脏衰竭。在用一个心肌肥大小鼠模型所做的一项研究中，研究人员对这种转变是如何发生的有了新的认识。研究结果发表在最新一期的《Nature》杂志上。
研究发现，当实验动物心脏增大时，会形成新的血管来支持它。但大约两星期后，肿瘤抑制蛋白P53会在心脏细胞中积累，血管形成被阻断，小鼠出现心脏衰竭。通过抑制P53或通过促进血管形成来影响这一过程，也许可以成为阻止心肌肥大向心脏衰竭发展的一种手段。
FIGURE 1. Cardiac hypertrophy, function and angiogenesis after TAC
a, Heart weight/body weight (HW/BW) after TAC. b, Cross-sectional area (CSA) of cardiomyocytes and the number of microvessels per cardiomyocyte. c, Double-immunostaining for dystrophin (brown) and PECAM (black) of the TAC hearts. Scale bar, 20 m. d, Echocardiographic analysis. FS, fractional shortening; LVPWTd, left ventricular posterior wall thickness. Asterisk, P < 0.05, two asterisks, P < 0.001 versus day 0; dagger, P < 0.01 versus day 14. Error bars indicate s.e.m.; n = 7 for a; n = 3 for b; n = 5 for d. e, Cardiac fibrosis. Scale bar, 50 m. f, g, RNase protection assay (f) and western blot analysis (g) in the TAC heart.
原文出处：
Nature Volume 446 Number 7134
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload p444
Masanori Sano, Tohru Minamino, Haruhiro Toko, Hideyuki Miyauchi, Masayuki Orimo, Yingjie Qin, Hiroshi Akazawa, Kaoru Tateno, Yosuke Kayama, Mutsuo Harada, Ippei Shimizu, Takayuki Asahara, Hirofumi Hamada, Shuhei Tomita, Jeffrey D. Molkentin, Yunzeng Zou and Issei Komuro
doi:10.1038/nature05602
First paragraph | Full Text | PDF (681K) | Supplementary information
See also: Editor's summary
相关基因：
HIF1A
Official Symbol: HIF1A and Name: hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens]
Other Aliases: HIF-1alpha, HIF1-ALPHA, MOP1, PASD8
Other Designations: ARNT interacting protein; hypoxia-inducible factor 1, alpha subunit; member of PAS superfamily 1
Chromosome: 14; Location: 14q21-q24
MIM: 603348
GeneID: 3091
TP53
Official Symbol: TP53 and Name: tumor protein p53 (Li-Fraumeni syndrome) [Homo sapiens]
Other Aliases: LFS1, TRP53, p53
Other Designations: p53 tumor suppressor; tumor protein p53
Chromosome: 17; Location: 17p13.1
MIM: 191170
GeneID: 7157
