根据一篇发表于Journal of the American Chemical Society网络版的文章「Aggregation of Rod-Coil Block Copolymers Containing Rigid Polyampholyte Blocks in Aqueous Solution」中，巨分子与接口研究所(Macromolecules and Interfaces Institute)的研究人员S. Richard Turner合成了一种新的带电、杆状共聚物家族，它的长度只有人类头发的直径，可以带正电或负电，也可以交替地携带正电及负电。
这种小的杆状分子可以自行组装，而且聚集后的结构在生理食盐水中相当稳定。这项研究结果也将于3月25-29日在芝加哥举行的，第233届美国化学学会会议中发表。
这项研究的早期结果建议，这些带电的聚合物，可以经由类似DNA等自然聚合物之同电荷间的交互作用而自行聚集。稳定的自组结构，将可以应用于药物传递和基因传递系统中。这些独特的共聚物也可以成为研究DNA的教育模型。
(资料来源 : Bio.com)
部分英文原文：
J. Am. Chem. Soc., 129 (13), 3832 -3833, 2007. 10.1021/ja070422+ S0002-7863(07)00422-2
Web Release Date: March 10, 2007 Copyright © 2007 American Chemical Society
Aggregation of Rod-Coil Block Copolymers Containing Rigid Polyampholyte Blocks in Aqueous Solution
Min Mao and S. Richard Turner*
Department of Chemistry, Macromolecules and Interfaces Institute (MII), Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0344
Received January 19, 2007
Abstract:
Rod-coil block copolymers containing rigid polyampholyte blocks were designed and synthesized by RAFT copolymerization. The rigid polyampholyte blocks were formed by hydrolysis of alternating copolymers of N,N,N',N'-tetraethyl-4,4'-diaminostilbene with maleic anhydride, and the flexible coil block consists of poly(oligo(ethylene glycol)methacrylate). The rod-coil block copolymers form polyion complex (PIC) aggregates even when the polyampholyte blocks are charge imbalanced. The aggregates did not dissociate upon the addition of high concentrations of NaCl unlike the dissociation of flexible polyampholytes in NaCl solution. These unique solution properties are induced by like-charge attractions of the rigid polyampholytic alternating copolymer chains.
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