生物谷报道：心脏病发作后幸存下来的病人，其大面积的组织是创伤后修复的。Thomas Jefferson 大学和Alfred I. DuPont 儿童医院的研究者已经证实有一种蛋白，它可以在心脏病发作后促进损伤的修复过程。研究者们在纽奥尔良市于3.27一年一度的美国学院的科学会议上提出了这项研究。他们应用小鼠来研究纤连蛋白-2（一种细胞外基质蛋白），以便更好的理解它在损伤修复中所发挥的作用。纤连蛋白-2存在于胚胎发育和各种损伤后组织重塑过程中。细胞外基质为组织细胞提供一种连接，可能在损伤后的组织重塑过程中提供结构上的完整性，但关于其功能还知之甚少。
通过比较正常的和缺乏纤连蛋白-2的小鼠在心脏病发作后24和72小时的心脏创伤的结果，研究者发现，缺乏纤连蛋白-2的小鼠其急性损伤修复大大延迟。72小时后，他们发现缺乏纤连蛋白-2的小鼠其梗死的面积大于比正常的小鼠。缺乏纤连蛋白-2的小鼠心脏病发作后的损伤修复过程比较慢，是由于延缓了损伤区域瘢痕组织的形成。这项研究表明，纤连蛋白-2促进心脏损伤修复可能与一种促损伤修复的生长因子TGF的帮助有关。
研究者目前正在研究纤连蛋白-2在慢性心力衰竭的过程中的作用。
原文出处：
Extracellular Matrix Protein, Fibulin-2, Enhances Acute Wound Healing After Experimental Myocardial Infarction In Mice
After surviving a heart attack, a big issue for a patient is the healing of the wound. Researchers at Thomas Jefferson University and Alfred I. DuPont Hospital for Children have found something that may help; they've identified a protein that contributes to the wound healing process after a heart attack.
The researchers presented the study at the American College of Cardiology's 56th Annual Scientific Session in New Orleans on March 27 at 10 am (abstract 1025-75).
They used mice to examine the role of Fibulin-2, an extracellular matrix protein, to better understand its role in wound repair. Fibulin-2 is naturally occurring in embryonic development as well as in tissue remodeling after various injuries.
Extracellular matrix, which embraces and connects cells within the tissue, may provide structural integrity during tissue remodeling after injury, but little is known about its functional aspects.
By comparing the results of heart attacks in mice that did not have the Fibulin-2 protein with normal mice at both 24 and 72 hours after the heart attack, the researchers found that acute wound healing was significantly delayed in the mice lacking Fibulin-2. After 72 hours, they found that the damaged (infarct) area was much larger in the mice lacking Fibulin-2.
The researchers found that the wound healing process was much slower in the mice lacking Fibulin-2 after a heart attack due to delayed scar tissue formation in the damaged area. The study demonstrated that Fibulin-2 facilitates heart wound healing probably with the help of (TGF)-?, a growth factor that promotes wound healing.
The researchers are also currently looking into the role of Fibulin-2 as a factor in the development of chronic heart failure.
http://www.medicalnewstoday.com/medicalnews.php?newsid=66455
相关基因：
LOC131984
similar to fibulin 2 precursor; Fibulin-2 (H. sapiens) [Homo sapiens]
Chromosome: 3; Location: 3p25.1
GeneID: 131984
This record was discontinued.
