生物谷报道：来自Alabama大学Birmingham分校（UAB）的科学家最近发现，红酒中的物质可以减少患前列腺癌的风险。
科学家在研究中让雄性老鼠摄入红酒中的植物成分——白藜芦醇（resveratrol），这是一种有抗氧化和抗癌作用的物质。其它含有该物质的食物包括葡萄、覆盆子、花生和蓝莓等。结果显示老鼠患前列腺癌的风险降低了87%，并且这种抗癌效果在食用含掺有粉状白藜芦醇食物后7个月最佳。
而其它患上了症状较轻的前列腺癌的老鼠中，48%的肿瘤生长速度相比未服用白藜芦醇的老鼠有所停止或放缓。
此项研究发表在《肿瘤杂志》（Journal of Carcinogenesis）的8月在线版上。
研究主要负责人，UAB药理和毒物学博士Coral Lamartiniere认为，研究结果再次证实红酒中的白藜芦醇除了对心脏健康有好处外，还拥有强大的化学防癌作用。在2006年5月发表于同一刊物的文章中，UAB小组曾发现白藜芦醇能降低雌性老鼠乳腺癌风险。
Lamartiniere表示他的研究小组对于红酒和浆果中类似白藜芦醇的多酚物质强大的化学抗癌作用感到很惊喜。Lamartiniere和其他科学家表示他们正在着手测试人类白藜芦醇的摄入量，以确定多大浓度能带来防癌效果。UAB小组在老鼠实验中使用的量相当于一人每天喝一瓶红酒，这无疑太多。医生通常建议适度饮用红酒：男性平均每天2杯，女性1杯。 （教育部科技发展中心）
原文链接：http://www.physorg.com/news107785087.html
原始出处:
Journal of Carcinogenesis 2007, 6:3 doi:10.1186/1477-3163-6-3
Published 16 March 2007
Genistein chemoprevention of prostate cancer in TRAMP mice
Jun Wang1 , Isam-Eldin Eltoum2 ,3 and Coral A Lamartiniere1 ,3
1Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA
2Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
3Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA
Abstract
Epidemiological studies suggest an inverse association between soy intake and prostate cancer risk. Genistein, the predominant phytoestrogen in soy food, has been proposed as a potential chemopreventive agent due to its anti-estrogen and tyrosine kinase inhibitory effects. To determine the most effective period for genistein chemoprevention, the Transgenic adenocarcinoma mouse prostate (TRAMP) model was used. The treatments were 250 mg genistein/kg AIN-76A diet 1) prepubertally only, 2) in adulthood only or 3) through out life. Controls received AIN-76A diet. By 28 weeks of age, 100% TRAMP mice fed control diet developed prostatic intraepithelial neoplasia (PIN) or adenocarcinomas with 6%, 16%, 44% and 34% developing high grade PIN, well differentiated, moderately differentiated and poorly differentiated prostatic adenocarcinomas, respectively. Prepubertal only (1–35 days postpartum) and adult only genistein treatments (12 – 28 weeks) resulted in 6% and 29% decreases in poorly-differentiated cancerous lesions compared with controls, respectively. The most significant effect was seen in the TRAMP mice exposed to genistein throughout life (1–28 weeks) with a 50% decrease in poorly-differentiated cancerous lesions. In a separate experiment in castrated TRAMP mice, dietary genistein suppressed the development of advanced prostate cancer by 35% compared with controls. Of the tumors that developed in castrated TRAMP mice, 100% were poorly-differentiated in contrast to the 37% of noncastrated TRAMP mice that developed poorly-differentiated tumors. ICI 182,780 (ICI), genistein and estrogen down-regulated androgen receptor (AR), estrogen receptor alpha (ER-α) and progesterone receptor (PR) in the prostates of C57BL/6 mice, and act independently of ER. Our data obtained in intact and castrated transgenic mice suggest that genistein may be a promising chemopreventive agent against androgen-dependent and independent prostate cancers.
